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NAD + metabolism in neurodegenerative disorders Neurodegenerative diseases are a heterogeneous group of diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), which are characterized by progressive degeneration of the structure and function of the peripheral and central nervous system, with the characteristics like the accumulation of misfolded and aggregated proteins that are associated with severe proteotoxic stress (Fig

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doi: 10.1002/jnr.490110209